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KMID : 0861120110150030039
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Korean Journal of Oriental Preventive Medicine
2011 Volume.15 No. 3 p.39 ~ p.49
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A Case Study on Drug Prescription for Vascular Dementia in Western and Oriental Medicine
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Choi Seong-Hun
Cheon Woo-Hyun
Baek Kyung-Min
Han Chang-Hyun
Jeon Won-Kyung
Kam Cheol-Woo
Lee Young-Joon
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Abstract
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Objectives: Vascular dementia is the second common cause of dementia after Alzheimer’s disease. It
assumed that the ratio of prescription drugs on vascular dementia are quite different from each hospital
in Western medicine or Oriental medicine, respectively. The aim of this research is to collect and analyze
the ratio of prescription drugs on vascular dementia in Western medicine or Oriental medicine in
university hospitals.
Methods: We collected and analyzed the data related to prescriptions on vascular dementia in the department
of neurology in three university hospitals(A, B, C) and in the department of internal medicine in
two Oriental medicine hospitals(Daegu Haany Oriental Hospital, Dong Eui Oriental Hospital).
Results: In the department of neurology in A university hospital, donepezil(69.1%), memantine(14.0%),
rivastigmine(12.3%), galantamine(4.5%) were prescribed in order. In B university hospital, galantamine
(57.8%) donepezil(33.3%), rivastigmine(6.7%), donepezil with memantine(4.4%) were prescribed. In C university
hospital, donepezil(62.0%), rivastigmine(25.0%), galantamine(7.0%) memantine(6.0%) were prescribed. The
average frequencies of prescribed medication in the department of neurology in A, B, C university hospitals
were donepezil(54.8%), galantamine(23.1%), rivastigmine(14.7%), memantine(7.4%). In Oriental medicine
hospitals, various prescriptions have been used for vascular dementia. Among them, Ansincheongnoetang
(安神淸腦湯) and Gamijihangeumja(加味地黃飮子) were often prescribed in Daegu Haany Oriental Hospital,
and Bojungikgitang(補中益氣湯) in Dong Eui Oriental Hospital, too.
Conclusions: Cholinesterase inhibitors such as donepezil, galantamine, rivastigmine and NMDA receptor
inhibitor like memantine have been used as a drug of choice for vascular dementia in all surveyed university
hospitals. In oriental hospitals, various prescriptions have been used for vascular dementia.
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KEYWORD
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Vascular dementia, Cholinesterase inhibitor, Prescription, Memantine
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